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- drugbank:DB04858 type drugbank_vocabulary:Drug assertion.
- drugbank:DB04858 label "Tirapazamine [drugbank:DB04858]" assertion.
- drugbank:DB04858 seeAlso DB04858 assertion.
- drugbank:DB04858 identifier "drugbank:DB04858" assertion.
- drugbank:DB04858 description "Tirapazamine (SR-4233) is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia. Thus, tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors. Cells in these regions are resistant to killing by radiotherapy and most anticancer drugs. Thus the combination of tirapazamine with conventional anticancer treatments is particularly effective. As of 2006, tirapazamine is undergoing phase III testing in patients with head and neck cancer and gynecological cancer, and similar trials are being undertaken for other solid tumor types. [Wikipedia]" assertion.
- drugbank:DB04858 title "Tirapazamine" assertion.
- drugbank:DB04858 bio2rdf_vocabulary:identifier "DB04858" assertion.
- drugbank:DB04858 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB04858 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB04858" assertion.
- drugbank:DB04858 bio2rdf_vocabulary:x-identifiers.org DB04858 assertion.
- drugbank:DB04858 drugbank_vocabulary:drugbank-id "DB04858" assertion.
- drugbank:DB04858 drugbank_vocabulary:x-cas cas:27314-97-2 assertion.
- drugbank:DB04858 drugbank_vocabulary:x-chemspider chemspider:31132 assertion.
- drugbank:DB04858 drugbank_vocabulary:x-pubchemcompound pubchem.compound:33776 assertion.
- drugbank:DB04858 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:10426937 assertion.
- drugbank:DB04858 drugbank_vocabulary:x-wikipedia wikipedia:Tirapazamine assertion.