Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB05007_nanopub.RAT_da8N12yvuJ2uXPzQBRoWICEk0O1m3QcCxG26qDgDs#assertion>. }
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- drugbank:DB05007 type drugbank_vocabulary:Drug assertion.
- drugbank:DB05007 label "XL647 [drugbank:DB05007]" assertion.
- drugbank:DB05007 seeAlso DB05007 assertion.
- drugbank:DB05007 identifier "drugbank:DB05007" assertion.
- drugbank:DB05007 description "XL647 is a potent inhibitor of multiple RTKs implicated in driving tumor cell proliferation and tumor vascularization (blood vessel formation). XL647 inhibits the EGF, HER2, and VEGF RTKs, each of which is a target of currently approved cancer therapies. In addition, XL647 inhibits EphB4, an RTK that is highly expressed in many human tumors and plays a role in promoting angiogenesis. In a broad array of preclinical tumor models including breast, lung, colon and prostate cancer, XL647 demonstrated potent inhibition of tumor growth and causes tumor regression. In cell culture models, XL647 retains significant potency against mutant EGFRs that are resistant to current EGFR inhibitors." assertion.
- drugbank:DB05007 title "XL647" assertion.
- drugbank:DB05007 bio2rdf_vocabulary:identifier "DB05007" assertion.
- drugbank:DB05007 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB05007 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB05007" assertion.
- drugbank:DB05007 bio2rdf_vocabulary:x-identifiers.org DB05007 assertion.
- drugbank:DB05007 drugbank_vocabulary:drugbank-id "DB05007" assertion.
- drugbank:DB05007 drugbank_vocabulary:x-cas cas: assertion.