Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB05460_nanopub.RA8N2kPrBaCsOf7DFmSikwj3CSWexUHmxpBd4nsITxKCI#assertion>. }
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- drugbank:DB05460 type drugbank_vocabulary:Drug assertion.
- drugbank:DB05460 label "TLK-199 [drugbank:DB05460]" assertion.
- drugbank:DB05460 seeAlso DB05460 assertion.
- drugbank:DB05460 identifier "drugbank:DB05460" assertion.
- drugbank:DB05460 description "TLK199 is a small molecule drug that is an analog inhibitor of glutathione S-transferase P1-1. It acts intracellularly on the MAPK signaling pathway by activating ERK2. TLK199 has myelostimulant activity in preclinical rodent models and human bone marrow cultures, and differentiates granulocytes and monocytes in HL60 cells. TLK199 is a candidate designed to stimulate the formation of bone marrow cells that are precursors to granulocytes and monocytes (white blood cells), erythrocytes (red blood cells) and platelets. Many conditions are characterized by depleted bone marrow, including myelodysplastic syndrome (MDS), a form of pre-leukemia in which the bone marrow produces insufficient levels of one or more of the 3 major blood elements (white blood cells, red blood cells and platelets). It might also be relevant as an adjunct therapy since a reduction in blood cell levels is also a common, toxic effect of many standard chemotherapeutic drugs." assertion.
- drugbank:DB05460 title "TLK-199" assertion.
- drugbank:DB05460 bio2rdf_vocabulary:identifier "DB05460" assertion.
- drugbank:DB05460 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB05460 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB05460" assertion.
- drugbank:DB05460 bio2rdf_vocabulary:x-identifiers.org DB05460 assertion.
- drugbank:DB05460 drugbank_vocabulary:drugbank-id "DB05460" assertion.
- drugbank:DB05460 drugbank_vocabulary:x-cas cas: assertion.
- drugbank:DB05460 drugbank_vocabulary:x-chemspider chemspider:4470493 assertion.
- drugbank:DB05460 drugbank_vocabulary:x-pubchemcompound pubchem.compound:5310939 assertion.