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- drugbank:DB06262 type drugbank_vocabulary:Drug assertion.
- drugbank:DB06262 label "Droxidopa [drugbank:DB06262]" assertion.
- drugbank:DB06262 seeAlso DB06262 assertion.
- drugbank:DB06262 identifier "drugbank:DB06262" assertion.
- drugbank:DB06262 description "Droxidopa is a precursor of noradrenaline that is used in the treatment of Parkinsonism. It is approved for use in Japan and is currently in trials in the U.S. The racaemic form (dl-threo-3,4-dihydroxyphenylserine) has also been used, and has been investigated in the treatment of orthostatic hypotension. There is a deficit of noradrenaline as well as of dopamine in Parkinson's disease and it has been proposed that this underlies the sudden transient freezing seen usually in advanced disease. Though L-DOPS has been used in Japan and Southeast Asia already for some time, it is also currently in clinical trials at the phase III point in the United States (U.S.), Canada, Australia, and throughout Europe. Provided L-DOPS successfully completes clinical trials, it could be approved for the treatment of neurogenic orthostatic hypotension (NOH) as early as 2011. Additionally, phase II clinical trials for intradialytic hypotension are also underway. Chelsea Therapeutics obtained orphan drug status (ODS) for L-DOPS in the U.S. for NOH, and that of which associated with Parkinson's disease , pure autonomic failure, and multiple system atrophy, and is the pharmaceutical company developing it in that country." assertion.
- drugbank:DB06262 title "Droxidopa" assertion.
- drugbank:DB06262 bio2rdf_vocabulary:identifier "DB06262" assertion.
- drugbank:DB06262 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB06262 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB06262" assertion.
- drugbank:DB06262 bio2rdf_vocabulary:x-identifiers.org DB06262 assertion.
- drugbank:DB06262 drugbank_vocabulary:drugbank-id "DB06262" assertion.
- drugbank:DB06262 drugbank_vocabulary:x-cas cas:23651-95-8 assertion.
- drugbank:DB06262 drugbank_vocabulary:x-chemspider chemspider:391994 assertion.
- drugbank:DB06262 drugbank_vocabulary:x-pubchemcompound pubchem.compound:443940 assertion.
- drugbank:DB06262 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:99443239 assertion.
- drugbank:DB06262 drugbank_vocabulary:x-kegg kegg:D01277 assertion.
- drugbank:DB06262 drugbank_vocabulary:x-pharmgkb pharmgkb:PA164748386 assertion.
- drugbank:DB06262 drugbank_vocabulary:x-wikipedia wikipedia:Droxidopa assertion.
- drugbank:DB06262 drugbank_vocabulary:x-ndc ndc:76320-100 assertion.