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- drugbank:DB06693 type drugbank_vocabulary:Drug assertion.
- drugbank:DB06693 label "Mevastatin [drugbank:DB06693]" assertion.
- drugbank:DB06693 seeAlso DB06693 assertion.
- drugbank:DB06693 identifier "drugbank:DB06693" assertion.
- drugbank:DB06693 description "Mevastatin or compactin is a cholesterol-lowering agent isolated from <i>Penicillium citinium</i>. It was the first discovered agent belonging to the class of cholesterol-lowering medications known as statins. During a search for antibiotic compounds produced by fungi in 1971, Akira Endo at Sankyo Co. (Japan) discovered a class of compounds that appeared to lower plasma cholesterol levels. Two years later, the research group isolated a compound structurally similar to hydroxymethylglutarate (HMG) that inhibited the incorporation of acetate. The compound was proposed to bind to the reductase enzyme and was named compactin. Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. Mevastatin is a pro-drug that is activated by <i>in vivo</i> hydrolysis of the lactone ring. It has served as one of the lead compounds for the development of the synthetic compounds used today." assertion.
- drugbank:DB06693 title "Mevastatin" assertion.
- drugbank:DB06693 bio2rdf_vocabulary:identifier "DB06693" assertion.
- drugbank:DB06693 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB06693 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB06693" assertion.
- drugbank:DB06693 bio2rdf_vocabulary:x-identifiers.org DB06693 assertion.
- drugbank:DB06693 drugbank_vocabulary:drugbank-id "DB06693" assertion.
- drugbank:DB06693 drugbank_vocabulary:x-cas cas:73573-88-3 assertion.
- drugbank:DB06693 drugbank_vocabulary:x-chemspider chemspider:393586 assertion.
- drugbank:DB06693 drugbank_vocabulary:x-pdb pdb:114 assertion.
- drugbank:DB06693 drugbank_vocabulary:x-pubchemcompound pubchem.compound:446154 assertion.
- drugbank:DB06693 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:99443247 assertion.
- drugbank:DB06693 drugbank_vocabulary:x-ahfs ahfs:24:06.08 assertion.
- drugbank:DB06693 drugbank_vocabulary:x-kegg kegg:C13963 assertion.
- drugbank:DB06693 drugbank_vocabulary:x-wikipedia wikipedia:Mevastatin assertion.
- drugbank:DB06693 drugbank_vocabulary:x-bindingdb bindingdb:50011036 assertion.