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- drugbank:DB08885 type drugbank_vocabulary:Drug assertion.
- drugbank:DB08885 label "Aflibercept [drugbank:DB08885]" assertion.
- drugbank:DB08885 seeAlso DB08885 assertion.
- drugbank:DB08885 seeAlso aflibercept-ophthalmic.html assertion.
- drugbank:DB08885 seeAlso eylea-drug.htm assertion.
- drugbank:DB08885 identifier "drugbank:DB08885" assertion.
- drugbank:DB08885 description "Aflibercept is a recombinant fusion protein that comprises of two main components: the vascular endothelial growth factor (VEGF) binding portions from the extracellular domains of human VEGF receptors 1 and 2 which is then fused to the Fc portion of human IgG1. Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It contains approximately 15% glycosylation to give a total molecular weight of 115 kDa. All five putative N-glycosylation sites on each polypeptide chain predicted by the primary sequence can be occupied with carbohydrate and exhibit some degree of chain heterogeneity, including heterogeneity in terminal sialic acid residues, except at the single unsialylated site associated with the Fc domain. Aflibercept, as an ophthalmic agent, is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Ziv-aflibercept, under the brand name Zaltrap, was developed as an injection for treatment of metastatic colorectal cancer. FDA approved in November 18, 2011 and EMA approved in November 2012." assertion.
- drugbank:DB08885 title "Aflibercept" assertion.
- drugbank:DB08885 bio2rdf_vocabulary:identifier "DB08885" assertion.
- drugbank:DB08885 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB08885 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB08885" assertion.
- drugbank:DB08885 bio2rdf_vocabulary:x-identifiers.org DB08885 assertion.
- drugbank:DB08885 drugbank_vocabulary:drugbank-id "DB08885" assertion.
- drugbank:DB08885 drugbank_vocabulary:x-cas cas:862111-32-8 assertion.
- drugbank:DB08885 drugbank_vocabulary:x-ahfs ahfs:52:92 assertion.
- drugbank:DB08885 drugbank_vocabulary:x-atc atc:S01LA05 assertion.
- drugbank:DB08885 drugbank_vocabulary:x-kegg kegg:D09574 assertion.
- drugbank:DB08885 drugbank_vocabulary:x-wikipedia wikipedia:Aflibercept assertion.
- drugbank:DB08885 drugbank_vocabulary:x-ndc ndc:61755-005-02 assertion.