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- drugbank:DB08905 type drugbank_vocabulary:Drug assertion.
- drugbank:DB08905 label "Formestane [drugbank:DB08905]" assertion.
- drugbank:DB08905 seeAlso DB08905 assertion.
- drugbank:DB08905 seeAlso formestane.html assertion.
- drugbank:DB08905 identifier "drugbank:DB08905" assertion.
- drugbank:DB08905 description "Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. Formestane has poor oral bioavailability, and thus must be administered forthnightly (bi-weekly) by intramuscular injection. Some clinical data has suggested that the clinically recommended dose of 250mg was too low. With the discovery of newer, non-steroidal and steroidal, aromatase inhibitors which were orally active and less expensive than formestane, formestane lost popularity. Currently, formestane (categorized as an anti-estrogenic agent) is prohibited from use in sports in accordance to the regulations of the World Anti-Doping Agency. It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn." assertion.
- drugbank:DB08905 title "Formestane" assertion.
- drugbank:DB08905 bio2rdf_vocabulary:identifier "DB08905" assertion.
- drugbank:DB08905 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB08905 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB08905" assertion.
- drugbank:DB08905 bio2rdf_vocabulary:x-identifiers.org DB08905 assertion.
- drugbank:DB08905 drugbank_vocabulary:drugbank-id "DB08905" assertion.
- drugbank:DB08905 drugbank_vocabulary:x-cas cas:566-48-3 assertion.
- drugbank:DB08905 drugbank_vocabulary:x-atc atc:L02BG02 assertion.
- drugbank:DB08905 drugbank_vocabulary:x-kegg kegg:D07260 assertion.
- drugbank:DB08905 drugbank_vocabulary:x-wikipedia wikipedia:Formestane assertion.