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- source_evidence_literature type ECO_0000212 NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_assertion description "[We examined toll-like receptor 4 (TLR4) as a candidate gene for AMD susceptibility because: (i) the TLR4 gene is located on chromosome 9q32-33, a region exhibiting evidence of linkage to AMD in three independent reports; (ii) the TLR4-D299G variant is associated with reduced risk of atherosclerosis, a chronic inflammatory disease with subendothelial accumulation; (iii) the TLR4 is not only a key mediator of proinflammatory signaling pathways but also linked to regulation of cholesterol efflux and (iv) the TLR4 participates in phagocytosis of photoreceptor outer segments by the RPE.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_assertion evidence source_evidence_literature NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_assertion SIO_000772 15829498 NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_assertion wasDerivedFrom befree-20140225 NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_assertion wasGeneratedBy ECO_0000203 NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.
- befree-20140225 importedOn "2014-02-25" NP914675.RAN2CnACiiZ5opUyHgbeA2gjXC-BTN125MZdXc2YDC9Ms130_provenance.