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- source_evidence_literature type ECO_0000212 NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_assertion description "[While many such markers have been proposed, few have stood the test of time; this is due to various reasons outlined in detail in this chapter.Of the reasons that have affected the usefulness and broad applicability of CLL biomarkers a few stand out as recurrent: lack of independent effects of individual markers on prognosis; the use of arbitrary cutoffs when using continuous variables; technical challenges in validity, reproducibility, and reliability (classical test characteristics); and lack of marker validation in prospectively identified CLL patient cohorts.Nonetheless, a few useful prognostic markers (CLL interphase FISH, immunoglobulin heavy chain variable region mutation status) have been identified, and others are still in transition to widespread clinical applications (TP53 mutations, SNP array-based elevated genomic complexity).As CLL therapy transitions from genotoxic combination therapies to targeted therapies, it will be of importance to reestablish the usefulness of our current understanding of individual CLL traits in CLL prognosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_assertion evidence source_evidence_literature NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_assertion SIO_000772 24014298 NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_assertion wasDerivedFrom befree-2016 NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_assertion wasGeneratedBy ECO_0000203 NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.
- befree-2016 importedOn "2016-02-19" NP1108555.RAiRa3JwU8peCwlBbblEgSYbP4wXPHuHgwaN98y72mpmg130_provenance.