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- source_evidence_literature type ECO_0000212 NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_assertion description "[Systemic monocytes, tissue resident macrophages, dendritic cells and microglia have specific roles in immune surveillance and maintenance of tissue homeostasis and are key regulator and effector cells of the local immune response to acute and chronic tissue injury.Two major signalling pathways that differentially define trafficking behaviour and activation of systemic and local myeloid cell populations in response to exogenous and endogenous inflammatory stimuli are the Ccl2-Ccr2 and the Cx3cl1-Cx3cr1 chemokine pathways.Alterations in these pathways have been implicated in controlling myeloid cell activation during normal ageing and in age-related retinal degenerations, including age-related macular degeneration (AMD).We review the evidence for how altered chemokine signalling in acute and chronic inflammatory conditions regulate local and systemic myeloid cell responses in the retina and how this may contribute to or attenuate pathology in inherited and age-related retinal diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_assertion evidence source_evidence_literature NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_assertion SIO_000772 24664727 NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_assertion wasDerivedFrom befree-2016 NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_assertion wasGeneratedBy ECO_0000203 NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.
- befree-2016 importedOn "2016-02-19" NP1167046.RA2fA5l_UzI2TIHPnBbNOLU8vISkq2YG2wLesJY1VeT0A130_provenance.