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- source_evidence_literature type ECO_0000212 NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_assertion description "[We review here research in this field that has provided several translational opportunities, ranging from diagnostic tests to gene therapy, such as (1) a test in renal proximal tubule cells isolated from the urine of humans that may determine the salt-sensitive phenotype by analyzing the recruitment of dopamine D1 receptors to the plasma membrane; (2) the presence of common GRK4 gene variants that are not only associated with hypertension but may also be predictive of the response to antihypertensive therapy; (3) genetic testing for polymorphisms of the dopamine D2 receptor that may be associated with hypertension and inverse salt sensitivity and may increase the susceptibility to chronic kidney disease because of loss of the antioxidant and anti-inflammatory effects of the renal dopamine D2 receptor, and (4) in�vivo renal selective amelioration of renal tubular genetic defects by a gene transfer approach, using adeno-associated viral vectors introduced to the kidney by retrograde ureteral infusion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_assertion evidence source_evidence_literature NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_assertion SIO_000772 25134060 NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_assertion wasDerivedFrom befree-2016 NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_assertion wasGeneratedBy ECO_0000203 NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.
- befree-2016 importedOn "2016-02-19" NP1211653.RACJBWBxOUI1SePoEGf8xq_U1qoC-TDm82pvUd2AFRfFM130_provenance.