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- source_evidence_literature type ECO_0000212 NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_assertion description "[We analyzed structural motifs of peptides bound to HLA-DR4 (DRB1*0405 and DRB1*0406) and DR9 (DRB1*0901) and found that: (a) AxxBxC motif where A, B, and C are hydrophobic, hydrophobic, and neutral, respectively, is important for binding to DR4; (b) Gln (Q) or Ser at position C allow high-affinity binding specific to DRB1*0406 which is strongly associated with insulin autoimmune syndrome; (c) among human insulin-derived peptide fragments, the TSICSLYQLE of the human insulin alpha chain, which is exposed only under reducing conditions, has the highest affinity specific to DRB1*0406 by binding with the IxxLxQ motif; (d) a short-term human insulin-specific T cell line recognizes a peptide fragment containing the IxxLxQ motif as a major T cell epitope; and (e) in the AxxB motif, where A and B need to be hydrophobic for binding to DR9, neutral Ser is exceptionally allowed at position B.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_assertion evidence source_evidence_literature NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_assertion SIO_000772 9119530 NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_assertion wasDerivedFrom befree-20150227 NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_assertion wasGeneratedBy ECO_0000203 NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.
- befree-20150227 importedOn "2015-02-27" NP456010.RAPxzogooYX9cxj0kMcm8Ku6ID_Packn_7w_qBXLH8_Jc130_provenance.