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- source_evidence_literature type ECO_0000212 NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_assertion description "[Each example of an activated ras gene showed a mutation at the 61st codon of the protein, with the exception of one melanoma which showed a mutation at codon 13 of the N-ras gene; (2) all the melanomas displaying an activated ras gene had a similar cell surface phenotype and appear to come from a similar phase of differentiation; (3) 5-6% of noncultured primary and metastatic melanomas have mutated ras genes; (4) no ras gene mutations were found in any precursor lesion, specifically normal nevi and dysplastic nevi; (5) immunoperoxidase analysis of paraffin-embedded specimens indicated no quantitative or qualitative alterations in p21 expression that correlate with tumor progression; (6) there were no observable differences in p21 expression between melanoma cells growing exponentially or in plateau phase, or between melanoma cells with or without ras mutations; nor were any cell kinetic differences found between cells with and without mutated ras genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_assertion evidence source_evidence_literature NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_assertion SIO_000772 2682463 NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_assertion wasDerivedFrom befree-20150227 NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_assertion wasGeneratedBy ECO_0000203 NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.
- befree-20150227 importedOn "2015-02-27" NP598764.RAJR9nUZe3CJc4jxE4GhSBYWF4Y4RuvCSei4XeOmanvOk130_provenance.