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- source_evidence_literature type ECO_0000212 NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- source_evidence_literature label "DisGeNET evidence - LITERATURE" NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- source_evidence_literature comment "Gene-disease associations inferred from text-mining the literature." NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_assertion description "[Our results show that: (1) tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, synergically stimulate NO production in cultured cholangiocytes through an increase in NOS2 gene and protein expression; (2) micromolar concentrations of NO inhibit forskolin-stimulated cAMP production by adenylyl cyclase (AC), cyclic adenosine monophosphate (cAMP)-dependent fluid secretion, and cAMP-dependent Cl(-) and HCO(3)(-) transport mediated by cystic fibrosis transmembrane conductance regulator (CFTR) and anion exchanger isoform 2, respectively; (3) cholestatic effects of NO and of proinflammatory cytokines are prevented by NOS-2 inhibitors and by agents (manganese(III)-tetrakis(4-benzoic acid)porphyrin [MnTBAP], urate, trolox) able to block the formation of reactive nitrogen oxide species (RNOS); (4) NOS2 expression is increased significantly in the biliary epithelium of patients with primary sclerosing cholangitis (PSC).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_assertion evidence source_evidence_literature NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_assertion SIO_000772 12612912 NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_assertion wasDerivedFrom befree-20150227 NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_assertion wasGeneratedBy ECO_0000203 NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.
- befree-20150227 importedOn "2015-02-27" NP985539.RAWfIZ0JeuDyUJh8gbxn-Kuz8PevRgx5AU0AEmPjK42Bw130_provenance.