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- _4 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _3 value "Interestingly, it has been previously reported that leptin and adiponectin can stimulate AMPK (19, 22). However, in the rats injected with Adv-resistin, the inhibition of AMPK activation appeared to be independent of adiponectin or leptin levels, as the levels of these two adipokines were not altered by hyper-resistinemia (leptin: Adv-resistin, 7.03 2.56 ng/ml; Adv-lacZ, 7.74 3.12 ng/ml; adiponectin: Adv-resistin, 8.66 1.1 ul/ml; Adv-lacZ, 7.94 2.30 ul/ml; Table 1). We found a uniform decrease in AMPK activity as measured by AMPK phosphorylation, in liver, muscle, and fat. Interestingly, however, it is known that both leptin and adiponectin can increase AMPK activity, but as leptin and adiponectin levels were comparable between the rats injected with Adv-resistin and those injected with Adv-lacZ, and as resistin is an adipokine that generally has effects opposite to those of leptin and adiponectin, it is likely that resistin decreases AMPK activity." provenance.
- _3 wasQuotedFrom 15254589 provenance.
- assertion hadPrimarySource 15254589 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _3 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _4 provenance.
- large_corpus.bel version "20131211" provenance.