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_3 label "Selventa" provenance.
_2 value "Interestingly, HO-1 has been shown to interact with cellular and synthetic proteins, which may modulate the activity of the enzyme. Interactions with amyloid precursor proteins, which are implicated in the pathogenesis of Alzheimer disease, have been demonstrated to inhibit HO-1 activity, resulting in a compromised stress defense (Takahashi et al., 2000; Takahashi and Snyder, 2000; Wagener et al., 2003b). On the other hand, Buelow and colleagues have demonstrated that the synthetic peptide RDP1258 can bind HO-1 and cause increased HO-1 expression and activity in vivo (Cuturi et al., 1999; Magee et al., 1999). This protein has further shown to be highly effective in ameliorating a range of inflammatory conditions (Cuturi et al., 1999; Oberyszyn et al., 2001). Thus, HO seems to be cytoprotective by limiting the influx of activated inflammatory cells and by ameliorating the extent of cellular necrosis and apoptosis in injured tissues. On the other hand, too high HO-1 expression may also cause tissue injury by the generation of high levels of iron or result in bilirubinemia (Suttner and Dennery, 1999). V. The Heme-Heme Oxygenase System Top Previous Next The heme-heme oxygenase system is tightly involved in both physiological as well as pathophysiological processes, such as cytoprotection, apoptosis, and inflammation. A better understanding of the complex heme-heme oxygenase system may provide us with novel tools to combat diverse conditions, such as inflammation, wound healing, transplant rejection, sickle cell disease, and cancer (Lane, 1998; Maines, 2000; Wagener et al., 2003a). A. The Heme-Heme Oxygenase-1 System and Apoptosis Under oxidative and inflammatory conditions necrosis and apoptosis may occur, which result in the release of large amounts of heme and subsequently exacerbation of the inflammatory process and cellular injury. However, under these conditions the stress-responsive protein HO-1 will be immediately induced as well. " provenance.
_2 wasQuotedFrom 12869663 provenance.
assertion hadPrimarySource 12869663 provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _2 provenance.
large_corpus.bel authoredBy _3 provenance.
large_corpus.bel version "20131211" provenance.