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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "These findings suggest that Par-4, Daxx, and ZIPK may form a ternary complex, though further work is required to verify this hypothesis. ZIPK, Daxx, and Par-4 collaborate in caspase activation and apoptosis induction. Cells transfected individually with plasmids encoding ZIPK, Par-4, or Daxx did not exhibit an increase in apoptosis at the concentrations of plasmid DNA used here (Fig. 6A). In contrast, the percentage of apoptotic cells was increased two- to threefold in cultures of cells coexpressing ZIPK with either Par-4 or Daxx (Fig. 6A). Similarly, coexpressing Daxx with Par-4 elevated the percentage of apoptotic cells by two to threefold compared to the percentage due to expression of either Daxx or Par-4 alone (Fig. 6A). The most striking increase in apoptosis, however, was achieved by expressing all three proteins together. When expressed together, ZIPK, Daxx, and Par-4 induced an approximately sixfold increase in apoptosis." provenance.
- _5 wasQuotedFrom 12917339 provenance.
- assertion hadPrimarySource 12917339 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "20131211" provenance.