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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "used siRNAto specifically deplete b-catenin to investigate the potential of accumulated b-catenin to trigger activation of the UPR. Despite treatment with enzastaurin, phosphorylation of eIF2a and induction of CHOP, 2 key markers of the early UPR, were markedly inhibited on depletion of b-catenin (Figure 2D top). Moreover, enzastaurin-induced up-regulation of p21(WAF) was also abrogated on depletion of b-catenin...These findings indicate that enzastaurininduced accumulation of v-catenin activates the PERK-eIF2a-CHOP branch of the UPR and thereby contributes to early growth arrest induced by enzastaurin via p21(WAF)...Similar to enzastaurin, the PKC inhibitor BIM I also induced b-catenin accumulation and triggered activation of the UPR in both MM.1S #basically saying that enzastaurin-induction of UPR is dependent on CTNNB1" provenance.
- _5 wasQuotedFrom 19018094 provenance.
- assertion hadPrimarySource 19018094 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "1.4" provenance.