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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "Bay 11-7082, an inhibitor of I{kappa}B phosphorylation, and NF-{kappa}B activation was used to determine whether chemokine induction by PGN is NF-{kappa}B dependent. Concentrations of Bay 11-7082 between 1.0 and 5 �M were used according to published studies. RA synovial fibroblasts were pretreated with Bay 11-7082 for 30 min, washed and subsequently stimulated with PGN for 4 h. Total RNA was then extracted and RANTES, GCP-2, and MCP-2 mRNA quantified by real-time PCR. There was a dose-dependent decrease of mRNA levels of the tested chemokines ranging from marked reduction upon treatment with 1 �M Bay 11-7082 to almost complete inhibition in the RA synovial fibroblasts pretreated with 5 �M Bay 11-7082. " provenance.
- _4 wasQuotedFrom 14707104 provenance.
- assertion hadPrimarySource 14707104 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.