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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "Jagged1 on tumor cells binds to Notch receptor(s) on endothelial cells. Upon ligand binding, the Notch intracellular domain (NICD) is released from the endothelial cell plasma membrane by the secretase-dependent proteolytic cleavages of Notch receptor. The NICD then translocates to the nucleus, where it interacts with the CSL (named for mammalian CBF1/RBP, Drosophila Su(H), and C. elegans Lag-1) transcription repressor to activate the transcription of target genes.The basic-helix-loop-helix proteins (bHLH) Hairy/Enhancer of Split (Hes1, -5, and -7) and Hes-related proteins (Hey1, -2, and -L) are the best-characterized downstream targets." provenance.
- _5 wasQuotedFrom 16023591 provenance.
- assertion hadPrimarySource 16023591 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "1.4" provenance.