Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RABKYaKYaxsRO6YxloTryo7CIqD9bTCRKlzXxk6dVKwnU#provenance>. }

Showing items 1 to 11 of 11 with 100 items per page.

_6 label "Selventa" provenance.
_5 value "MITF in the commitment, proliferation, and survival of melanocytes before and/or during neural crest cell migration beta-catenin, a multifunctional protein which can either bind to E-cadherins as an integral part of the actin cytoskeleton which anchors cell cell adhesion, or can act as a transcriptional coactivator by interacting with the T-cell transcription factor (TCF)/lymphoid enhancer binding factor (LEF) family of DNA binding proteins in the nucleus. In the absence of Wnt-signals, beta-catenin is targeted for degradation via phosphorylation by a complex consisting of glycogen synthase kinase (GSK)3beta, axin, and adenomatous polyposis coli protein (APC). Wnt signals lead to inactivation of GSK3beta, and thus stabilize beta-catenin levels in the cell which increase transcription of downstream target genes. In human melanoma, stabilizing mutations of beta-catenin have been found in a significant fraction of established cell lines. Importantly, in primary human melanoma specimens, almost one third display aberrant nuclear accumulation of beta-catenin, although generally without evidence of direct mutations within the beta-catenin gene itself In mammalian cells, Wnt-3a, was also shown to induce MITF expression" provenance.
_5 wasQuotedFrom 12235125 provenance.
assertion hadPrimarySource 12235125 provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _5 provenance.
large_corpus.bel authoredBy _6 provenance.
large_corpus.bel version "20131211" provenance.