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- _7 label "Selventa" provenance.
- _7 comment "support@belframework.org" provenance.
- small_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." provenance.
- small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
- _6 value "Hydroxylation at two prolyl residues (Pro402 and Pro564 in human HIF-1?) mediates interactions with the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex that targets HIF-? for proteasomal destruction28, 29, 30, 34. Each site can interact independently with VHL E3, potentially contributing to the extremely rapid proteolysis of HIF-? that is observed in oxygenated cells34. These sites contain a conserved LxxLAP motif and are targeted by a newly defined prolyl hydroxylase activity, that in mammalian cells is provided by three isoforms termed PHD (prolyl hydroxylase domain) 1-3 (refs. 31,32)." provenance.
- _6 wasQuotedFrom 12778166 provenance.
- assertion hadPrimarySource 12778166 provenance.
- small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
- small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
- assertion wasDerivedFrom small_corpus.bel provenance.
- assertion wasDerivedFrom _6 provenance.
- small_corpus.bel authoredBy _7 provenance.
- small_corpus.bel version "1.6" provenance.