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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "J. Adaptors Adaptors are molecules that are devoid of intrinsic catalytic activity; after binding to the PDGF receptors through their SH2 domains, they connect the receptor with downstream effector molecules. The regulatory subunits of PI 3-kinase and Grb2, which form complexes with the catalytic subunit of PI 3-kinase and Sos, respectively, are examples of adaptor molecules that have been discussed already. Other adaptor molecules that bind to PDGF receptors are Shc, Grb7, Nck, and Crk. After binding of Shc to the PDGF receptors, it becomes phosphorylated on Tyr-317, which can be recognized by Grb2/Sos and thus contributes to Ras activation (398), as well as on Tyr-239 and Tyr-240, which initiates another signaling pathway leading to induction of c-myc (148)." provenance.
- _4 wasQuotedFrom 10508235 provenance.
- assertion hadPrimarySource 10508235 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.