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- _8 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _7 value "OMIM summary: Human: Dual-specificity phosphatases, such as DUSP10, negatively regulate the mitogen-activated protein kinase (MAPK) cascade by dephosphorylating both the threonine and tyrosine residues in TxY motifs in MAPKs ({1:Masuda et al., 2000}). Pubmed titles from omim summary: (summary is not available from this source) Entrez Gene GeneRifs summary: Human: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK." provenance.
- _7 wasQuotedFrom _6 provenance.
- assertion hadPrimarySource _6 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- _6 title "DUSP10 harvester omim" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _7 provenance.
- large_corpus.bel authoredBy _8 provenance.
- large_corpus.bel version "20131211" provenance.
- _6 identifier "DUSP10 harvester omim" provenance.
- _6 type "Online Resource" provenance.