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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "This morphological change represents one of the hallmarks of an EMT. To determine whether the molecular alterations of an EMT occurred in these cells, we examined the localization of several adherens junction proteins, such as E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Immunostaining showed that all four proteins disappeared from cell membrane in the Twist-express- ing MDCK cells compared to their strong membrane staining in the control cells (Figure 5B). We also observed complete loss of E-cadherin, alpha-catenin, and gamma-catenin proteins by immunoblotting (Figure 5C). In contrast, the expression of fibroblast markers, including fibronectin, vimentin, smooth-muscle actin, and N-cad- herin, whose expression has been shown to correlate positively with the EMT (Boyer and Thiery, 1993), was strongly induced (Figures 5B and 5C). Hence, both the morphological and molecular changes in the Twistexpressing MDCK cells demonstrated that these cells had undergone an EMT." provenance.
- _5 wasQuotedFrom 15210113 provenance.
- assertion hadPrimarySource 15210113 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _5 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "20131211" provenance.