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- _8 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _7 value "The insulin receptor tyrosine kinase is capable of inducing phosphorylation and activation of the cGMP-inhibited phosphodiesterase and several protein serine phosphatases (most likely protein phosphatases 1, 2A, and 2C). Phosphatidyl inositol 3-kinase A has been demonstrated as an essential component in the insulin-stimulated activation of the cGMP-inhibited phosphodiesterase but, as previously mentioned, Protein kinase A can also fullfill this this role in the absence of insulin. Thus, insulin inhibits the cAMP cascade (including the activation of hormone senstive lipase) through cleavage of cAMP and direct dephosphorlyation of protein kinase A-activated substrates Dephosphrylation also activates acetyl-CoA carboxylase, the enzyment that catalyzes the first committed step in de novo fatty acid synthesis, and fatty acyl-CoA synthetase, the first enzyme in the triacylglycerol synthetic pathway." provenance.
- _7 wasQuotedFrom _6 provenance.
- assertion hadPrimarySource _6 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- _6 title "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 10" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _7 provenance.
- large_corpus.bel authoredBy _8 provenance.
- large_corpus.bel version "20131211" provenance.
- _6 identifier "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 10" provenance.
- _6 type "Book" provenance.