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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "IFN-gamma-induced BAL1/BBAP transactivation requires JAK2 kinase and an intact IRF element. We next analyzed the downstream signaling molecules required for IFN-gamma-mediated BAL1/BBAP induction. For this reason, HEK293 cells were transfected with a luciferase reporter vector driven by the BAL1/BBAP minimal promoter (BAL1 109 458Luc) and treated with IFN-gamma in the presence or absence of the chemical JAK2 inhibitor AG490 (used at doses that specifically inhibit JAK2 kinase activity without nonspecific toxicity). AG490 inhibited IFNgamma-induced BAL1/BBAP promoter activity in a dose-dependent manner, directly implicating JAK2 and the associated STAT-1 and IRF transcription factors in this process (data not shown)." provenance.
- _5 wasQuotedFrom 16809771 provenance.
- assertion hadPrimarySource 16809771 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "20131211" provenance.