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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "Mice homozygous for a tyr757-to-phe (Y757F) mutation, which inactivated the Shp2-binding domain of gp130, developed normally into superficially healthy adults, but they showed age-dependent enlargement of the stomach, proximal small intestine, and spleen. Histologic examination revealed hyperproliferative lesions within the antropyloric mucosa, often circumferential, resulting in gastric outlet obstruction. Tebbutt et al. (2002) noted that the gastric pathology was essentially phenocopied in Tff1 (113710) null mice, and biochemical analysis of gastric Tff1 levels in mice with the Shp2-binding domain mutation confirmed a 75% reduction in comparison with wildtype mice; levels of Tff3 were elevated in the mutant mice. Gp130 mice, with a knock-in mutation abrogating SHP2-Ras-ERK signaling (Y757F), developed gastric adenomas by 3 months of age." provenance.
- _5 wasQuotedFrom 12219085 provenance.
- assertion hadPrimarySource 12219085 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "20131211" provenance.