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_6 label "Selventa" provenance.
_5 value "The sensitivity of the Rb phosphatase in intact cells to various cell-permeable cytotoxins also points to PP1 (396). D. Exit From the Pachytene Stage in Yeast Meiosis In yeast, a premature exit from the pachytene stage after the initiation of meiotic recombination is prevented by the so-called \"pachytene checkpoint\" (reviewed in Ref. 303). An active checkpoint results in the phosphorylation and activation of protein kinase Mek1, which keeps its substrate Red1 phosphorylated (29, 102). When recombination has ended in late pachytene, the checkpoint is inactivated by the dephosphorylation of Red1 by PP1 (30). Overexpression of PP1 bypasses the checkpoint precociously. The nature of the regulatory subunit(s) associated with this meiotic function of PP1 remains unclear. A number of findings originally pointed to Gip1, a PP1- binding protein that is specifically expressed in middle meiosis and that is essential for sporulation (372). Thus it was reported that 1) Gip1 was required for the targetting of PP1 to chromosomes in late pachytene, 2) yeast cells lacking Gip1 displayed a pachytene arrest that was similar to that of cells with constitutively active Mek1 or with a deficient version of PP1, and 3) this arrest was alleviated by overexpression of PP1 (30). However, in a more recent study, deletion of the Gip1-encoding gene was found not to affect meiotic progression, but instead to interfere with the normal localization of sporulation-specific septins and the deposition of spore wall material (347). Strikingly, replacement of PP1 by a mutant version that fails to interact with Gip1 yielded a similar phenotype. IV. CELL CYCLE ARREST AND APOPTOSIS PP1 not only activates the Rb protein at the M/G1 transition (see sect. IIIC), but it is also implicated in the control of Rb at the G1/S transition and in Rb-mediated cell cycle arrest." provenance.
_5 wasQuotedFrom 14715909 provenance.
assertion hadPrimarySource 14715909 provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
assertion wasDerivedFrom _5 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
large_corpus.bel authoredBy _6 provenance.
large_corpus.bel version "1.4" provenance.