Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#provenance>. }

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_7 label "Selventa" provenance.
_7 comment "support@belframework.org" provenance.
small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
_6 value "Co-transfection of luciferase reporter plasmids containing these sequences along with expression plasmids encoding either an activated ?-catenin containing mutations in the GSK-3h phosphorylation sites (?-catenin/4145) or with a TCF3-VP16 fusion protein demonstrated that both promoter sequences could be activated by transcriptional mediators of Wnt signaling (Figs. 7A and B). Addition of both h-catenin/4154 and TCF3-VP16 resulted in cooperative activation of both promoters (Figs. 7A and B). Furthermore, a dominantnegative TCF3 construct repressed both BMP4 and N-myc promoters (Figs. 7C and D). Chromatin immunoprecipitation assays show that ?-catenin associates with the conserved LEF/TCF DNA binding sites located in the BMP4 and N-myc promoters, indicating direct regulation of these promoters by canonical Wnt signaling (Figs. 7E and F). Together, these results demonstrate that BMP4 and Nmyc are targets of Wnt/?-catenin signaling in lung airway epithelium." provenance.
_6 wasQuotedFrom 15907834 provenance.
assertion hadPrimarySource 15907834 provenance.
small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
assertion wasDerivedFrom small_corpus.bel provenance.
assertion wasDerivedFrom _6 provenance.
small_corpus.bel authoredBy _7 provenance.
small_corpus.bel version "1.6" provenance.