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- _3 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _2 value "Two mechanisms have been identified to explain how insulin receptors promote insulin secretion in b cells. Insulin stimulates exocytosis of secretory vesicles (Aspinwall et al., 1999); exocytosis of insulin feeds back to promote transcription of the insulin gene, an effect mediated by insulin receptors, IRS2, and PI 3-kinase (Leibiger et al., 1998). This role for IRS2 in b cells helps to explain the observation that IRS2 knockout mice developed diabetes because of failure of insulin secretion to compensate for insulin resistance" provenance.
- _2 wasQuotedFrom 10199397 provenance.
- assertion hadPrimarySource 10199397 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _2 provenance.
- large_corpus.bel authoredBy _3 provenance.
- large_corpus.bel version "20131211" provenance.