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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value " PI3K. PI3Ks are activated during TLR/IL-1R signalling, as a result of the direct interaction of the PI3K p85 regulatory subunit with the receptor82. This interaction involves the SRC homology 2 (SH2) domain of the p85 subunit and a domain in the receptor containing the motif Tyr-Xaa-Xaa-Met. The subsequent association of the p110 catalytic subunit of PI3Ks results in complete activation, leading to the phosphorylation and activation of its downstream target, AKT. Interestingly, the PI3K-binding motif Tyr-Xaa-Xaa-Met, where Xaa denotes any amino acid, is present only in a subset of TLRs: TLR1, TLR2 and TLR6, but not TLR3, TLR4 or TLR5 (Ref. 83). However, a putative PI3K-binding site (Tyr257-Lys258-Ala259-Met260) is present in the C-terminus of MyD88, and LPS stimulation has been shown to result in the tyrosine phosphorylation of MyD88 and the formation of a PI3K-MyD88 complex84." provenance.
- _5 wasQuotedFrom 15229469 provenance.
- assertion hadPrimarySource 15229469 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "1.4" provenance.