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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "FIG. 11. Proposed mechanism of regulation of smooth muscle contraction via inhibition of MLCP via the RhoA/ROK pathway and phosphorylation of myosin by ILK. Contractile agonists such as endothelin-1, angiotensin II, and vasopressin act via receptors that are coupled to both Gq/11 and G12/13 heterotrimeric G proteins (43). Gq/11 activates phospholipase Cb (PLCb), which hydrolyzes phosphatidylinositol 4,5- bisphosphate (PIP2) to generate inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol. Inositol 1,4,5-trisphosphate diffuses to the sarcoplasmic reticulum (SR), where it interacts with the inositol 1,4,5-trisphosphate receptor, a Ca21 release channel in the sarcoplasmic reticulum membrane, thereby triggering Ca21 release from the sarcoplasmic reticulum. The increase in [Ca21]i activates CaM-dependent MLCK and cross-bridge cycling." provenance.
- _4 wasQuotedFrom 11278951 provenance.
- assertion hadPrimarySource 11278951 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.