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- _4 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _3 value "TSA PROMOTES EXPRESSION OF FOLLISTATIN AND OF MARKERS OF MUSCLE REGENERATION We next wished to evaluate whether HDAC inhibitors may affect muscle regeneration in vivo. To this end, TSA was systemically delivered to adult female mice with subcutaneous micro-osmotic pumps. After 2 days of TSA treatment, the tibialis anterior muscles were in- jected with cardiotoxin. TSA delivery was continued for 3 additional days, after which the animals were sacrificed. At this time, muscle regeneration has been initi- ated (Charge and Rudnicki, 2004). The expression levels of follistatin in noninjured muscles was almost undetectable and increased upon injury (data not shown and Supplemental Figure S1). TSA administration further induced follistatin expression in injured muscles (40% in- crease, Figures 8A and 8B)." provenance.
- _3 wasQuotedFrom 15130492 provenance.
- assertion hadPrimarySource 15130492 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _3 provenance.
- large_corpus.bel authoredBy _4 provenance.
- large_corpus.bel version "1.4" provenance.