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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "The secreted factor FGF8, which is emanated from the isthmic organizer, is essential for the development of the midbrain and hindbrain (Liu and Joyner, 2001bGo; Nakamura et al., 2005Go; Wurst and Bally-Cuif, 2001Go). Therefore, we sought to dissect the possible relationship between the expression of Lmx1b and that of Fgf8 during mid/hindbrain development at stages prior to E10.5, the stage at which morphological defects in the MHB were first observed in the Lmx1b-/- embryo. In the wild-type embryo, Fgf8 expression was first observed in the presumptive MHB at the 4-somite stage (Fig. 4A). Strikingly, Fgf8 expression was absent in the Lmx1b-/- mutant at this stage (Fig. 4B). By contrast, Fgf8 expression in other regions of the mutant embryo was normal (arrowhead in Fig. 4B), suggesting specific regulation of Fgf8 expression by Lmx1b in the MHB." provenance.
- _4 wasQuotedFrom 17166916 provenance.
- assertion hadPrimarySource 17166916 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.