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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "Pharmacological inhibition of NF-kappaB blocked LPS-induced Cebpd transcription (Fig. 1d), and LPS-induced Cebpd mRNA (Fig. 1d) and protein (Fig. 1e) quantities were substantially increased in Atf3-null macrophages. Taken together, these data demonstrate that LPS-induced transcription of Cebpd is absolutely dependent on NFkappaB, and that NFkappaB-dependent Cebpd mRNA production is attenuated by ATF3. ChIP analysis demonstrated rapid and transient recruitment of Rel to the promoter of the Cebpd gene; maximal binding was seen 1 hr after stimulation with LPS (Fig. 1f). By contrast, LPS-stimulated ATF3 binding to the promoter of the Cebpd gene (over basal amounts) occurred after 3 h and was sustained (Fig. 1f). " provenance.
- _4 wasQuotedFrom 19270711 provenance.
- assertion hadPrimarySource 19270711 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.