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- _10 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _9 value "IAP, inhibitor of apoptosis; SMAC, second mitochondria-derived activator of caspase. In the death receptor pathway, ligands such as tumour-necrosis factor (TNF), FAS ligand (also known as CD95L), or TNF-related apoptosis-inducing ligand (TRAIL, also known as APO2 ligand (APO2L) or TNF ligand superfamily member 10 (TNFSF10)) interact with their respective death receptors (TNF receptor 1 (TNFR1), FAS (also known as CD95) and death receptor 4 (DR4, also known as TRAIL receptor 1 (TRAILR1)) or DR5 (also known as TRAILR2), respectively). These interactions ultimately lead to the recruitment of the FAS-associated death domain (FADD) and the activation of the protease caspase 8. Caspase 8 cleaves and activates caspase 3 and other downstream caspases, which results in a proteolytic cascade that gives rise to the cell death phenotype characterized by DNA fragmentation, chromatin condensation, cell shrinkage and membrane blebbing." provenance.
- _9 wasQuotedFrom 16239906 provenance.
- assertion hadPrimarySource 16239906 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _9 provenance.
- large_corpus.bel authoredBy _10 provenance.
- large_corpus.bel version "1.4" provenance.