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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "Downstream targets of PI3K in activated mast cells. Activation of class 1 PI3Ks generates the membrane-associated PtdInsP3 at the inner membrane, which provides inducible docking sites for pleckstrin homology (PH) domains of associating signaling molecules. The Ser/Thr kinases, PDK1 and AKT are subsequently phosphorylated and activated after Kit and Fc?RI activation. Major downstream targets of PI3K and AKT in mast cells, mTORC1, Btk, FOXO3a, and GSK3? pathways are shown (also see text) together with the specific responses in activated mast cells. Although depicted in the figure, and documented in other systems, it is not known whether AKT activation is regulated by the mTORC2 complex in mast cells. In addition, the function of GSK3? in activated mast cells still requires clarification. Whether these events are also initiated by GPCRs is currently unknown. For clarity other signaling events required for Fc?RI-and Kit-mediated responses in mast cells are not depicted in this figure. Readers are referred to recent review articles for further details of these processes [6,10]." provenance.
- _5 wasQuotedFrom 18775670 provenance.
- assertion hadPrimarySource 18775670 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "20131211" provenance.