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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "ARAP3 is a GTPase activating protein (GAP) for Rho and Arf GTPases that is implicated in phosphoinositide 3-kinase (PI 3-kinase) signalling pathways controlling lamellipodia formation and actin stress fibre assembly. Rho-family GTPases including Rac1, Cdc42 and RhoA play central roles in controlling actin cytoskeletal dynamics (Hall, 1998Go). The activities of these proteins are tightly controlled during cell adhesion to the ECM (Hynes, 2002Go; Etienne-Manneville and Hall, 2002Go). For example, Rac1 and Cdc42 are activated by integrin-mediated cell adhesion and, via specific effectors, stimulate the actin-nucleating activity of the Arp2/3 complex leading to actin polymerisation and lamellipodia and filopodia formation at the leading edge of cells" provenance.
- _4 wasQuotedFrom 15546919 provenance.
- assertion hadPrimarySource 15546919 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "1.4" provenance.