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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "Sodium-pump activity is closely linked to the intracellular calcium concentration via the sodium-calcium exchanger; this antiporter exchanges sodium and calcium in both directions across the sarcolemma. Changes in the concentration of either sodium or calcium ions inside or outside the cell affect the direction and magnitude of sodium-calcium exchange. Under normal conditions, the low intracellular sodium concentration favors sodium influx and clacium efflux. Some drugs take advantage of the functional coupling etween the sodium pump and the sodium-calcium exchanger to exert their effect as positive inotropes. Digoxin is the prototype of an inotropic agent that acts by inhibiting the sodium pump. A sarcolemmal calcium pump also helps to maintain calcium homeostasis by actively extruding calcium from the cytoplasm after cardiac contraction. A high concentration of ATP favors calcium removal (relaxation), both directly via the calcium pump and indirectly via the sodium pump." provenance.
- _4 wasQuotedFrom _3 provenance.
- assertion hadPrimarySource _3 provenance.
- _3 title "Golan Document" provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.
- _3 identifier "Golan Document" provenance.
- _3 type "Other" provenance.