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- _6 label "Selventa" provenance.
- _6 comment "support@belframework.org" provenance.
- small_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." provenance.
- small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
- _5 value "In contrast to protein-binding inhibition, evidence has shown that pVHL binds to both atypical PKC isoforms (l and z) through its b-domain, and in the case of activated aPKCl, mediates its turnover as part of the E3-ligase function of pVHL [39,40]. Although the functional significance of this inhibition remains elusive, given the central role for atypical PKCs (especially aPKCz) in establishing cell polarity in conjunction with PAR6 and the GTPase CDC42 [49], one could envisage a scenario whereby the loss of pVHL leads to altered cell polarity and, by extension, aberrant cell migration." provenance.
- _5 wasQuotedFrom 15350900 provenance.
- assertion hadPrimarySource 15350900 provenance.
- small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
- small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
- assertion wasDerivedFrom small_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- small_corpus.bel authoredBy _6 provenance.
- small_corpus.bel version "1.6" provenance.