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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "PMID 10620507 We found previously that protein kinase C-z (PKC-z) can phosphorylate and activate Raf-1 in a signalling complex. We report now that PKCz-Raf-1 interaction is mediated by 14-3-3 proteins in ?itro and in ?i?o. the results suggest that 14-3-3 binds both PKC-z (at phospho-Ser-186) and Raf-1 ina ternary complex. Complex formation was much stronger with a kinase-inactive PKC-z mutant than with wild-type PKC-z, supporting the idea that kinase activity leads to complex dissociation 14-3-3B and Q with its putative PKCz phosphorylation sites mutated enhanced co-precipitation between PKC-z and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-z weakens the complex in in vivo" provenance.
- _4 wasQuotedFrom 10433554 provenance.
- assertion hadPrimarySource 10433554 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.