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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "Ppara ligands decrease cytokine-mediated Vcam1 expression through effects on Nfkb signaling. Mechanisms involved reportedly include direct Ppara interaction with p65 and Ppara dependent expression of Ikba, sequestering the inactive p65/p50 complex in the cytoplasm. % These studies provide evidence that LPL acts on LDL(-) to generate Ppara ligands, thus countering the endothelial adhesion molecule expression induced by LDL(-) alone...In contrast, LPL hydrolysis of LDL(-) limits these responses by generation PPARa ligands, increasing IkBa expression with subsequent Nfkb inhibition.% LPL-treated LDL(-) suppressed NFkB and AP-1 activation, increasing expression of the PPARa target gene IkBalpha, although only in the genetic presence of PPARa and with intact LPL hydrolysis." provenance.
- _4 wasQuotedFrom 12878589 provenance.
- assertion hadPrimarySource 12878589 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _4 provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.