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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "HBP1 levels have been investigated for differentiation, in which there is an increase in many cell types (Parker et al., 1995 and Tevosian et al., 1997). Similarly, p38 MAPK activity is also linked with differentiation and recently, with senescence and tumor suppression (reviewed in Kyriakis and Avruch, 2001 and see below). The involvement of HBP1 in senescence is not known and under investigation. Conceivably, p38 MAPK, p21, and HBP1 may share similar pathways for differentiation, G1 progression, and possibly senescence. The identification of p21 as a substrate for the p38 MAPK was delineated through a systematic investigation of TGFb-induced cell cycle arrest for relevant kinases and substrates. Initially, these investigators found that p21 protein levels increased by a post-transcriptional mechanism and concluded that the SAPKs p38 MAPK and JNK were involved in stabilizing the p21 protein. A specific site on p21 (serine 190) was defined for p38 MAPK-mediated stabilization (Kim et al., 2002). " provenance.
- _5 wasQuotedFrom 15225871 provenance.
- assertion hadPrimarySource 15225871 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "1.4" provenance.