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_4 label "Selventa" provenance.
_3 value "Transformed Y783/795F cells also retained ability, albeit limited, to migrate across filters, whereas transformed cells with wild-type beta 1A were unable to transverse filters. Studies of single tyrosine mutants showed that the more important tyrosine for retaining ability to adhere, assemble focal contacts, and migrate is Y783. These results suggest that overactive phosphorylation of cytoplasmic residues of beta 1A, particularly Y783, accounts in part for the phenotype of v-src-transformed cells. (From text: v-src transformation causes increased ruffling of the plasma membrane in vitro and increased metastatic capacity in vivo (5, 6) but also results in loss of directed cell migration in a concentration gradient (chemotaxis) (24). Chemotaxis requires the fine control of cellular association with and release from the extracellular matrix; integrins play a central role in such associative and dissociative events (25?27).) Transformation with v-src caused GD25 and b1A-GD25 cells to lose the ability to adhere to fibronectin, nearly completely in the case of GD25 cells (Fig. 2). b1A-GD25 cells also adhered less well to laminin-1 after transformation (Fig. 2). Adhesion of v-src-transformed Y795F cells to fibronectin or laminin-1 was also less compared with nontransformed Y795F cells (Fig. 2 and data not shown). v-src-transformed Y783y795F and Y783F cells, in contrast, adhered as well to fibronectin or laminin-1 as nontransformed counterparts (Fig. 2 and data not shown). v-src-transformation caused loss of the migratory ability of b1A-GD25 and Y795F cells (Fig. 5)." provenance.
_3 wasQuotedFrom 11259684 provenance.
assertion hadPrimarySource 11259684 provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
assertion wasDerivedFrom _3 provenance.
large_corpus.bel authoredBy _4 provenance.
large_corpus.bel version "1.4" provenance.