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- _7 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _6 value "UCP-1 expression is under complex regulation; an enhancer element in the 5'flanking region of the ucp-1 gene has been described with putative binding sites for the thyroid hormone receptor, retinoic acid receptors and PPARs, as recently reviewed (Rousset et al. 2004). PPARc is a nuclear receptor essential for adipogenic differentiation in both WAT and BAT (Lowell 1999), that also displays a thermogenic function upon activation, with prostaglandings being the physiological ligands and TZD pharmacological activators (Rosen & Spiegelman 2001). Although b-adrenergic stimulation is the main physiological pathway that induces thermogenesis and UCP-1 expression in BAT, it is likely to be mediated by the induction of the PPARc coactivator (PGC-1), a master coactivator that binds PPARc, PPARa, thyroid hormone receptor and retinoic acid receptors (Puigserver & Spiegelman 2003)." provenance.
- _6 wasQuotedFrom 15777261 provenance.
- assertion hadPrimarySource 15777261 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _6 provenance.
- large_corpus.bel authoredBy _7 provenance.
- large_corpus.bel version "20131211" provenance.