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_5 label "Selventa" provenance.
_4 value "The gelsolin protein superfamily is a conserved family of proteins present in mammalian as well as in non-mammalian organisms. This review will focus on the role of gelsolin and gelsolin-related proteins in mammals. Gelsolin superfamily consists of seven different proteins: gelsolin, adseverin, villin, capG, advillin, supervillin and flightless I. All contain three or six homologous repeats of a domain named gelsolin-like (G) domain (fig. 1A). Gelsolin, a protein of 82-84 kDa, is the founding member of this family, exists as a cytoplasmic as well as a plasma isoform, and can bind, sever and cap actin filaments (reviewed in [2]). These isoforms are encoded by a single gene on chromosome 9 [3, 4]. The two messenger RNAs (mRNAs) encoding cytoplasmic and plasma isoforms result from alternative splicing and use alternative transcriptional initiation sites. Gelsolin is expressed in a wide variety of cell types. Its secreted form differs from the intracellular one by a 25-amino acid signaling peptide and the presence of a disulfide bond between cysteine residues at positions 188 and 201 [3, 5]. Recent studies show that the plasma gelsolin level decreases dramatically as a result of major trauma, and that reinfusion of gelsolin can protect against lung damage associated with major burn injury and other types of insults [6-8]." provenance.
_4 wasQuotedFrom 15526166 provenance.
assertion hadPrimarySource 15526166 provenance.
large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
large_corpus.bel description "Approximately 61,000 statements." provenance.
assertion wasDerivedFrom _4 provenance.
assertion wasDerivedFrom large_corpus.bel provenance.
large_corpus.bel authoredBy _5 provenance.
large_corpus.bel version "20131211" provenance.