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- _6 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _5 value "Akt plays a central role in controlling cell growth, proliferation, survival, and differentiation by phosphorylating a diverse number of protein substrates that contain a minimal consensus sequence of RXRXXS/T (Scheid and Woodgett, 2001). Among these are proteins implicated in metabolism, cell growth, and proliferation such as GSK3, mTOR, and TSC2, and proteins that play roles in apoptosis such as BAD, ASK1, and the Forkhead family of transcription factors FoxOs (Lawlor and Alessi, 2001). It is therefore important to understand how Akt can control such a diverse array of cellular functions. Akt is believed to couple the growth-factor-PI3K signaling pathway to the nutrient-regulated TORC1 signaling pathway (Wullschleger et al., 2006). Following growth-factor stimulation, activated Akt suppresses the GTPaseactivating protein (GAP) activity of the tumor suppressor TSC2/TSC1 complex by phosphorylating TSC2 (Gao et al., 2002; Inoki et al., 2002; Manning et al., 2002; Potter et al., 2002)." provenance.
- _5 wasQuotedFrom 16962653 provenance.
- assertion hadPrimarySource 16962653 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _5 provenance.
- large_corpus.bel authoredBy _6 provenance.
- large_corpus.bel version "20131211" provenance.