Nanopublications

Matches in Nanopublications for { ?s ?p ?o <http://www.tkuhn.ch/bel2nanopub/RAzr6zOOkwFtxJFFM8dCr-QCbwJUMyZQHOSi76mMbbGTo#provenance>. }

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_5 label "Selventa" provenance.
_5 comment "support@belframework.org" provenance.
small_corpus.bel license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" provenance.
_4 value "We next asked whether components of the JNK cascade could directly promote human epidermal neoplasia. We expressed either active MKK7 or c-Jun in primary keratinocytes and examined their capacity to promote tumorigenesis in combination with Ras in the absence of I?B?. First, we confirmed induction of AP1-dependent gene reporter activity by MKK7 in vitro (Supplementary Fig. S4). Surface skin grafts were then regenerated with primary keratinocytes expressing MKK7 and Ras; these developed into clinical tumors resembling SCC (Fig. 3A). Dermal invasion, one of the hallmarks of spontaneous human SCC, is apparent in tumors induced by MKK7 and Ras as revealed by both histologic appearance and BMZ disruption (Fig. 3B?C). MKK7 and Ras-induced neoplasia depends on intact AP1 function as concurrent expression of DNc-Jun prevents tumorigenesis (Fig. 3A?C)." provenance.
_4 wasQuotedFrom 17440097 provenance.
assertion hadPrimarySource 17440097 provenance.
small_corpus.bel title "BEL Framework Small Corpus Document" provenance.
small_corpus.bel description "Approximately 2000 hand curated statements drawn from 57 PubMeds." provenance.
assertion wasDerivedFrom small_corpus.bel provenance.
assertion wasDerivedFrom _4 provenance.
small_corpus.bel authoredBy _5 provenance.
small_corpus.bel version "1.6" provenance.