Matches in Nanopublications for { ?s ?p "It has been proposed that this regulation of PDE4D and other PDE4 long forms by MAPK constitutes feedback regulation. Inhibition of the PDE4 activity induces an increase in cAMP, and it has been speculated that the local activation of PKA in turn suppresses the MAPK cascade via phosphorylation of RAF (50). Pharmacological manipulation of the aortic smooth muscle cells shows that PKA phosphorylation and activation of PDE4D5 overcomes or obliterates the initial inhibition due to MAPK phosphorylation" ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _5 value "It has been proposed that this regulation of PDE4D and other PDE4 long forms by MAPK constitutes feedback regulation. Inhibition of the PDE4 activity induces an increase in cAMP, and it has been speculated that the local activation of PKA in turn suppresses the MAPK cascade via phosphorylation of RAF (50). Pharmacological manipulation of the aortic smooth muscle cells shows that PKA phosphorylation and activation of PDE4D5 overcomes or obliterates the initial inhibition due to MAPK phosphorylation" provenance.
- _5 value "It has been proposed that this regulation of PDE4D and other PDE4 long forms by MAPK constitutes feedback regulation. Inhibition of the PDE4 activity induces an increase in cAMP, and it has been speculated that the local activation of PKA in turn suppresses the MAPK cascade via phosphorylation of RAF (50). Pharmacological manipulation of the aortic smooth muscle cells shows that PKA phosphorylation and activation of PDE4D5 overcomes or obliterates the initial inhibition due to MAPK phosphorylation" provenance.